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Thursday, September 9
(agenda subject to change)

3:00 PM                Registration

4:00 - 4:30            Welcome and Overview of Program

Kenneth Sherman, MD, PhD - University of Cincinnati

Session 1            Epidemiology and Scope of Disease

Moderator: Kenneth Sherman, MD, PhD

4:30 – 5:10            HIV Changing Epidemiology, New Goals

John T. Brooks, MD - U.S. Centers for Disease Control and Prevention

5:10 – 5:45            HIV Treatment in 2021: When to Start, What to Start

Michael Saag, MD - The University of Alabama at Birmingham School of Medicine

5:45 – 6:30            Diseases Affecting the Liver in PLWH - What's Up, What's Down in 2021

Vincent Lo Re, MD, MSCE - University of Pennsylvania, Perelman School of Medicine

6:30 – 6:45            Selected Abstract

Declining Mortality for Patients with Human Immunodeficiency Virus (HIV) and Cirrhosis:  An Analysis of National Trends 

Alyson Kaplan, MD - New York Presbyterian Weill Cornella, Perelman School of Medicine

6:45 - 7:00             Panel Discussion

John T. Brooks, MD, Michael Saag, MD, Vincent Lo Re, MD, MSCE, Alyson Kaplan, MD

7:00 – 9:00            Poster Reception (all poster presenters at posters), Cocktail Reception

Friday, September 10
(agenda subject to change)

7:30 - 8:00 AM      Continental Breakfast

Session 2             Pathophysiology and Immunobiology of Liver Disease in HIV-Infected Patients 

Moderator:  David Thomas, MD

8:00 - 8:30             Role of CCR5 and CCR2 in Liver Disease

Shyam Kottilil MD, PhD - University of Maryland School of Medicine

8:30 – 9:00           The Microbiome in HIV

 Jennifer Price, MD, PhD - University of California, San Francisco

9:00 - 9:15            Selected Abstract

Proteomic Signature of Hepatic Fibrosis in HIV-Associated NAFLD  

Lindsay Fourman, MD  - Massachusetts General Hospital

9:15 - 9:45             Mechanisms of Liver Injury Relevant to the HIV-infected Patient

Raymond Chung, MD - Massachusetts General Hospital

9:45 - 10:00          Selected Abstract - Mini Presentations

Single-cell transcriptome profiling of liver fine needle aspirates and peripheral blood in HIV infection pre- and post-ART reveals monocyte/macrophage populations that contribute to liver disease progression.

Nadia Alatrakchi, MD, PhD - Massachusetts General Hospital

Human immunodeficiency virus activates the transcriptional coactivator YAP1 to promote liver fibrosis via lysophosphatidic acid receptors (LPAR)

Shadi Salloum, MD, PhD - Massachusetts General Hospital

The synthetic opioid fentanyl increases HIV replication and chemokine co-receptor expression in an HIV indicator cell line

Janani Madhuravasal Krishnan, PhD - University of Cincinnati

10:00 - 10:45        Break

Session 3            Hepatitis B and HIV

Moderator: Kenneth E. Sherman, MD, PhD - University of Cincinnati

10:45 – 11:20        New Targets for HBV Treatment

Debika Bhattacharya, MD, MSc - University of California Los Angeles

11:20 – 11:55        HBV Testing: How Do New Tests Inform Management and Cure Strategies

Chloe Thio, MD - Johns Hopkins University School of Medicine

11:55 – 12:30        Hepatitis B Vaccination in HIV-Infected Persons: Can We Do Better?

Kristen Marks, MD - Cornell University

12:30 – 12:45       Selected Abstract - Mini Presentations

HIV/HBV coinfection promotes liver fibrogenesis through an HIF-1?-dependent pathway

 Min Xu, MD - Massachusetts General Hospital

Chronic hepatitis delta phenotypes across Europe and Asia show various stages of viral clearance

Ameer Abutaleb, MD - University of Maryland

12:45 – 1:00         Panel Discussion

 Debika Bhattacharya, MD, MSc, Chloe Thio, MD, Kristen Marks, MD,  Min Xu, MD, Ameer Abutaleb, MD

1:05 – 2:00           Small Group Case-based Lunches with Experts (Groups of 10 or less meet in private dining)

Saturday, September 11
(agenda subject to change)

7:30 - 8:00 AM      Continental Breakfast

Session 4           Other Viral Hepatitis

Moderator: Michael Saag, MD

8:00 - 8:30            Treatment of HCV/HIV Coinfected Patient

Susanna Naggie, MD - Duke University School of Medicine

8:30 - 9:00            Elimination of HCV in PLWH

David Thomas, MD, MPH - Johns Hopkins University School of Medicine

9:00 - 9:30            SARS-CoV-2: At the Intersection of Liver Disease & 

Kenneth E. Sherman, MD, PhD - University of Cincinnati

9:30 - 9:45           Break

Session 5             ASH/NAFLD/NASH in HIV

Moderator: David Thomas, MD

9:45 - 10:15        Overlapping Diseases in HIV: ASH/NAFLD/NASH

Kathleen Corey, MD, MPH - Massachusetts General Hospital, Harvard Medical School

10:15 - 10:55        Treatments for NAFLD/NASH in PLWH

Jordan E. Lake, MD, MSc - The University of Texas

10:55 - 11:30        Food Insecurity: Links to Fatty Liver and Fibrosis

Marianna K. Baum, PhD, MS - Florida International University

11:30 - 11:45        Selected Abstract - Mini Presentations

HIV is independently associated with elevated FibroScan-AST (FAST) score, a non-invasive measurement of nonalcoholic steatohepatitis with significant activity and fibrosis

 Jennifer Price, MD, PhD - University of California, San Francisco

Risk Factors for the Development of Advanced Fibrosis in Patients with HIV and Hepatic Steatosis

 Zoe Memel, MD  - Massachusetts General Hospital 

Prevalence of Nonalcoholic Fatty Liver Disease and Predictors of Hepatic Fibrosis in an urban population with Human Immunodeficiency Virus (HIV) mono-infection

 Aurasch Moaven, MD - University of Vermont Medical Center

11:45 - 12:30        Behavioral Modification in PLWH: Alcohol, Diet and Drugs

Glenn Treisman, MD, PhD - Johns Hopkins University School of Medicine

Session 6            Research Agenda - Plans for the Next Two Years

Moderator: Kenneth E. Sherman, MD, PhD - University of Cincinnati

12:30 - 1:00          NIH Goals and Opportunities

Gerald B. Sharp, PhD - National Institute of Allergy and Infectious Diseases

1:00 - 1:20            Summary of Key Research Agenda Items

Kenneth E. Sherman, MD, PhD - University of Cincinnati

1:20 - 1:45            Conference Wrap-Up & To-go Lunches

Kenneth E. Sherman, MD, PhD - University of Cincinnati

2:30           Optional Group Hike

7:00            Group Dinner

Sponsored by University of Cincinnati
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Important Dates:

Registration - Now Open!
Housing Deadline - August 6, 2021

Faculty
Chair                                   
Kenneth E. Sherman, MD, PhD
Director, Division of Digestive Diseases
University of Cincinnati College of Medicine
Cincinnati, Ohio

Organizing Committee  
Marion Peters, MD
Chief of Hepatology Research
University of California San Francisco
San Francisco, California 

David Thomas, MD, MPH
Chief, Division of Infectious Diseases
Johns Hopkins University School of Medicine
Baltimore, Maryland